🔹 About This Episode:
In this episode, I’m joined by Amitay Eshel and Anastasia Khodzhaeva, the co-founders of Young Goose and leading innovators in longevity-based skincare. Together, we explore why youthful skin is fundamentally tied to cellular energy—not just appearance. We dive into how topical NAD+ can outperform oral and IV supplementation for skin health, why spermidine is a breakthrough molecule for restoring barrier function and promoting autophagy, and how methylene blue helps support mitochondrial repair, protects against oxidative stress, and improves recovery at the skin level.
We also unpack exosomes, how to properly layer them in a routine, and what truly differentiates science-backed longevity skincare from traditional “anti-aging” marketing. If you’re curious about the cutting edge of skin regeneration and want practical, research-grounded strategies to build resilient, healthier skin over time, this conversation is packed with insight and applicable takeaways.
Explore Young Goose: https://younggoose.com and Use code NAT10 (or 5NAT if you’re already a customer)
🔹 What you will learn:
→ Why NAD+ declines with age and how topical delivery can directly support skin energy and repair.
→ How spermidine and methylene blue activate autophagy and protect mitochondria for smoother, more resilient skin.
→ The key differences between longevity skincare vs. traditional anti-aging, and how to build a routine that actually works long-term.
🔹 What We Discuss:
Skin longevity: appearance vs resilience vs long-term health … 00:06:42
Why topical NAD matters for skin … 00:14:07
Importance and decline of NAD as we age … 00:18:26
Why spermidine was added to skincare … 00:21:00
How spermidine drives autophagy and hydration … 00:25:43
Spermidine’s impact on wrinkles and skin barrier … 00:29:06
Longevity skincare vs traditional approaches … 00:31:18
Methylene blue’s unique benefits and formulation … 00:34:04
Methylene blue vs other antioxidants … 00:36:16
Methylene blue’s role in recovery and protection … 00:46:13
Platelet-derived, quantified exosomes explained … 00:51:44
How to layer exosomes in your skincare … 01:01:13
Biggest myths in skin longevity … 01:02:41
Does topical NAD and spermidine really work? … 01:08:28
Where to start with Young Goose products … 01:19:33
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🔹 Learn More From Amitay and Anastasia below:
• Website: http://younggoose.com/
• Instagram: https://www.instagram.com/young_goose_skincare/
• YouTube: https://www.youtube.com/@AntiAgingSkinCareBiohacks2025
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🔹 Thank You To Our Sponsors For Making This Episode Possible:
• Digestive Bitters by Just Thrive – One capsule before eating helps your body absorb more nutrients, ease digestion, and leave you feeling light instead of weighed down. Head over to http://justthrivehealth.com/discount/NAT and use code NAT20 for 20% off.
• Puori: It’s minimally processed, made from pasture-raised cows’ milk, and it’s tested for over 200 contaminants every single batch. It’s also very Yummy! Go to http://puori.com/NAT and use code NAT for 20% off— it also applies to subscriptions so you’ll get nearly a third off the price.
• Thymus & Pineal BioRegulators by Natures Marvels – Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. Pineal Bioregulator supports your natural melatonin/circadian rhythm so you get the kind of sleep that underpins immune resilience. Head to http://profound-health.com/ and use code LONGEVITY15 for 15% off your first order.
🔹 Find more from Nathalie:
• YouTube: / @nathalieniddam9630
• Join Nat’s Membership Community: https://www.natniddam.com/the-longevity-community
• Sign up for Nats Newsletter: https://landing.mailerlite.com/webfor…
• Instagram: / nathalieniddam
• Website: NatNiddam.com
• Facebook Group: / biohackingsuperhumanperformance
#TheLongevityPodcast #Longevity #HealthySkin #NAD #Spermidine #MethyleneBlue #Biohacking #AntiAging #YoungGoose
