🔹 About This Episode:
In this episode, I’m joined by Dr. Brad Currier, Manager of Clinical Trials and a leading expert in the biology of muscle aging. We dive deep into mitophagy—the critical process your body uses to clean out dysfunctional mitochondria—and why the decline of this system predicts muscle loss, fatigue, slower recovery, inflammation, and accelerated aging. Dr. Currier breaks down the science behind Urolithin A (Mitopure), how it boosts mitochondrial biogenesis, why only a small percentage of people naturally produce enough of it, and what the newest human studies reveal about strength gains, endurance, performance, and recovery in both sedentary adults and elite athletes.
We also explore how improving mitochondrial function impacts immunity, inflammation, skin health, and even brain aging—revealing why Urolithin A has become one of the most studied longevity molecules today. You’ll learn the difference between Mitopure and generic Urolithin A, ideal dosing (500mg vs. 1g), timing strategies, stacking it with creatine and protein, and the most common myths surrounding antioxidants, pomegranate juice, and athlete-only benefits. If you’re looking to optimize your energy, protect your muscles, and support long-term healthy aging, this episode is packed with cutting-edge insights and actionable science to transform your performance at any age. Use code nat20 for 20% off at Timeline.com/nat20.
🔹 What you will learn:
→ Why mitophagy is the key to strong, youthful muscles—and why it declines as we age.
→ How Urolithin A (Mitopure) boosts energy, strength, recovery, and cellular longevity.
→ The science-backed dosing, timing, and stacking strategies to maximize mitochondrial health.
🔹 What We Discuss:
Episode start … 00:00:00
What is Mitophagy? Why It Matters as We Age … 00:04:53
Mitophagy in Athletes vs. General Population … 00:07:15
Urolithin A and Why Most People Can’t Make It … 00:12:12
What Mitopure Does: Mitophagy and Biogenesis … 00:24:10
Key Study: Strength Gains in Middle-Aged Adults … 00:26:43
Dose Guidance: 500mg vs. 1g … 00:31:39
Anti-Inflammatory Effects and Immune Health … 00:33:07
Benefits Beyond Muscle: Skin, Immunity, Brain … 00:35:01
Weightlifter Study: Performance in Trained Athletes … 00:40:34
Mitopure for Recovery and User Experiences … 00:46:41
How to Use Mitopure: Timing, Dosage, Consistency … 00:52:54
Protein, Creatine, and Mitopure: The Basics Stack … 00:53:41
Recovery, Cycling, and How Soon Benefits Appear … 00:58:44
Debunking Myths: Pomegranate, Antioxidant, Athletes Only … 01:10:26
Mitopure vs. Generic Urolithin A: Safety Concerns … 01:13:39
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🔹 Learn More From Brad Currier Below:
• Website: http://Timeline.com/nat20
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🔹 Thank You To Our Sponsors For Making This Episode Possible:
• Tranq Dart by Wizard Sciences – a multi-pathway sleep support from Wizard Sciences. It’s not a knockout pill; it’s a gentle nudge toward that wind-down zone. I take it about 30 minutes before bed, and it helps my body and brain sync up for sleep. Visit https://wizardsciences.com/ and use code NAT15 for 15% off. Sleep smarter, not harder.
• Tro Mune by Troscriptions – Cold season doesn’t have to take you out. I use Tro Mune—a nightly buccal troche with 75 mg cordycepin—to build immune resilience while I sleep. Take ½–1 before bed, and use it before you get sick or right when you feel it. http://Troscriptions.com, use NAT10, and get 10% off your first order.
• Thymus & Pineal BioRegulators – The Thymus Bioregulator helps keep immune response balanced and small human studies in older adults link it with healthier immune markers and fewer seasonal respiratory issues. The Pineal Bioregulator supports your natural melatonin/circadian rhythm—key when schedules and daylight change—so you get the kind of sleep that underpins immune resilience. Head to phttp://profound-health.com and use code LONGEVITY15 for 15% off your first order.
🔹 Find more from Nathalie:
• YouTube: / @nathalieniddam9630
• Join Nat’s Membership Community: https://www.natniddam.com/the-longevity-community
• Sign up for Nats Newsletter: https://landing.mailerlite.com/webfor…
• Instagram: / nathalieniddam
• Website: NatNiddam.com
• Facebook Group: / biohackingsuperhumanperformance
#TheLongevityPodcast #Longevity #Mitochondria #MuscleHealth #Mitophagy #UrolithinA #Mitopure #Biohacking #HealthyAging #AthleticPerformance #MitochondrialHealth
