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🔹 About This Episode:
Why do two people taking the same GLP-1 medication experience completely different weight loss results and side effects? In this episode, I’m joined by physician-scientist and medical geneticist Dr. Noura Abul-Husn to explore the emerging science of GLP-1 genetics, pharmacogenomics, and personalized medicine.
We also explore findings involving semaglutide, tirzepatide, the GIP receptor, genetic ancestry, polygenic risk scores, and population genomics, while discussing why genes are only one part of the picture. Dr. Abul-Husn explains the importance of combining genomic information with lifestyle, environment, biomarkers, and other health data—and why we should avoid genetic determinism.
🔹 What you will learn:
• How genetics may influence GLP-1 response, including weight loss results and side effects like nausea.
• How GLP-1 and GIP receptor gene variants may affect responses to semaglutide and tirzepatide.
• Why genes aren’t your destiny, and how lifestyle, environment, and ancestry also shape your health.
🔹 What We Discuss:
Introduction: podcast focus on genetics, peptides, and longevity… 00:00:00
Dr. Nora Abdul-Hussein’s background and journey in genomic medicine… 00:07:01
Prevention and population-scale genetics… 00:08:06
Power of genetic insights for personal lifestyle choices… 00:14:40
Barriers to adopting genetics in clinical practice… 00:16:41
Pharmacogenomics and the move toward personalized prescribing… 00:17:21
Launching a large-scale study on GLP-1 genetics… 00:19:41
Discovery: GLP-1 receptor gene variants linked to weight loss and nausea… 00:22:40
Risk calculators and personalized expectations for GLP-1s… 00:27:26
Broader genomics: diet, exercise, and response variability… 00:28:24
Avoiding genetic determinism and emphasizing holistic care… 00:29:29
Findings for tirzepatide and the GIP receptor… 00:34:20
Population differences and ancestry’s impact on results… 00:38:07
Is genetic information ready for prime time in GLP-1 therapy?… 00:41:12
Clinical implications beyond “calories in, calories out”… 00:43:01
GLP-1s: potential for non-weight related conditions… 00:44:48
Personalized medicine: integrating genomics with other data… 00:51:02
Reducing shame and embracing genes as tools for prevention… 01:00:02
Genomic information as an empowering health strategy… 01:01:30
Study insights and validation: self-reporting and sample diversity… 01:05:40
Protecting privacy and building trust in genomics… 01:13:32
Final thoughts: embrace your genes and use the data for healthspan… 01:20:10
Where to learn more and wrap-up… 01:21:18
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🔹 Find more from Nathalie:
• Join Nat’s Membership Community: https://www.natniddam.com/the-longevity-community
• Sign up for Nat’s Newsletter: https://landing.mailerlite.com/webfor…
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• Website: https://www.natniddam.com
• Dr. Bill Lawrence Episode: https://www.youtube.com/watch?v=jr2rcC1lNyM
#TheLongevityPodcast #GLP1 #GLP1Medications #GLP1WeightLoss #WeightLoss #Genetics #Semaglutide #Tirzepatide #PersonalizedMedicine #Pharmacogenomics #GeneticTesting #MetabolicHealth
