🔹 About This Episode:
What if your metabolism isn’t actually “broken” — but your hormones and mitochondria are signaling for help? In this episode, I’m joined by women’s health and metabolic resilience expert Siobhan Mitchell to unpack why so many women experience stubborn belly fat, brain fog, fatigue, inflammation, and body composition changes during perimenopause and menopause.
We dive deep into estrogen’s critical role in mitochondrial health, metabolism, glucose regulation, inflammation, cognitive performance, bone health, and healthy aging. Siobhan also explains why visceral fat accelerates aging and why many conventional wellness strategies stop working in midlife.
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🔹 What you will learn:
* Why women gain stubborn belly fat during perimenopause — and what’s really happening beneath the surface
* How estrogen impacts mitochondria, brain health, inflammation, and metabolic function
* The science behind S-equol, phytoestrogens, and supporting healthy aging through menopause
🔹 What We Discuss:
Introduction and host welcome … 00:00:00
Introducing Speaker B and focus on women’s health … 00:04:30
Growing interest in women’s health and clinical gaps … 00:05:12
Body composition and metabolic changes in perimenopause … 00:06:01
Hormonal shifts—not a broken metabolism … 00:09:21
Addressing the root cause versus band-aids like GLP-1 … 00:11:10
What’s happening beneath the surface in early perimenopause … 00:12:40
Role of estrogen in appetite, glucose, and fat storage … 00:13:12
Visceral fat, inflammation, and accelerated aging … 00:15:02
Estrogen’s connection to mitochondrial function … 00:16:15
Brain, muscle, and cognitive declines with estrogen loss … 00:16:44
Environmental and mitochondrial factors in PCOS … 00:21:09
Shift to belly fat and why fat storage changes … 00:22:58
Mitochondria, immune system, and autoimmunity in women … 00:29:16
Phytoestrogens, soy, and S-equol as hormone alternatives … 00:32:37
S-equol’s benefits: metabolic, bone, and brain health … 00:35:50
Soy fears, GMOs, and the purity of S-equol … 00:46:25
Microbiome, Bifidobacterium breve, and estrogen recycling … 00:49:18
GLP-1s versus supporting the root cause … 00:53:01
Optimizing estrogen signaling for health span and menopause timing … 00:55:20
When to use S-equol: timing and benefits … 00:55:54
Reversing visceral fat and lifestyle factors … 01:03:28
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🔹 Find more from Nathalie:
• Join Nat’s Membership Community: https://www.natniddam.com/the-longevity-community
• Sign up for Nats Newsletter: https://landing.mailerlite.com/webfor…
• Instagram: https://www.instagram.com/nathalieniddam/
• Website: https://www.natniddam.com
• Dr. Bill Lawrence Episode: https://www.youtube.com/watch?v=jr2rcC1lNyM
#TheLongevityPodcast #Perimenopause #Menopause #WomensHealth #Metabolism #Hormones #Longevity #Biohacking #Mitochondria #Estrogen #HealthyAging #BrainFog #BellyFat #GLP1
